acute ischemic stroke
Conditions
Interventions
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) aged >= 18 years; 2) acute ischemic stroke patients with first symptom onset; 3) symptom onset within 4.5 hours and eligible for criteria for IV-tPA treatment; 4) baseline NIHSS score range from 7 to 22; 5) written informed consent has been provided by patients or their legal proxies.
Exclusion criteria
Exclusion criteria: 1) Allergic to the drug components in this study. 2) Oral or intravenous application of other drugs similar to the mechanism of Floium Ginkgo Extract and Tertram Ethypyrazine Sodium Chloride injection before stroke onset(28 days). 3) Epilepsy with stroke onset. 4) Other lesions in the brain, history of mental illness. 5) History of chronic liver disease, liver and kidney dysfunction, elevated alanine aminotransferase (> 3 times the upper limit of normal), and elevated serum creatinine (> 2 times the upper limit of normal). 6) Pregnant or lactating women. 7) Other severe, advanced or terminal illnesses with life expectancy of less than 3 months, or inability to complete study follow-up due to other reasons. 8) Other circumstances that the researchers consider not appropriate for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| reperfusion improvement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of adverse events;Vascular recanalization;Ischemic penumbra;proportion of patients with a mRS score of 0-2;Proportion of patients with a NIHSS score at day 15, day 30, day 90 of 0-1 or a reduction of = 8 points from baseline;proportion of patients with a Barthel score=95; | — |
Countries
China
Contacts
Public ContactChuansheng Zhao
The First Hospital of China Medical University
Outcome results
None listed