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Effect of Guiluxian on the outcome of in vitro fertilization and embryo transfer in elderly women with low prognosis: a multicenter, double-blind, randomized, placebo-controlled trial

Effect of Guiluxian on the outcome of in vitro fertilization and embryo transfer in elderly women with low prognosis: a multicenter, double-blind, randomized, placebo-controlled trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR1900002843
Enrollment
Unknown
Registered
2019-12-16
Start date
2019-12-23
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertile patients with advanced age and low prognosis

Interventions

control group:Oral placebo
experimental group:Oral Guiluxian

Sponsors

Affiliated Hospital of Shandong University of traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 42 Years

Inclusion criteria

Inclusion criteria: In this study, we will recruit subjects who are 35 and 42 years old, meet the diagnostic criteria of western medicine infertility, insufficient ovarian reserve parameters (AFC = 10IU / L), poor ovarian response (i.e. oocytes obtained after standard ovarian stimulation <= 3), and meet the indications of IVF-ET.

Exclusion criteria

Exclusion criteria: (1) BMI >= 25Kg/m2; (2) those suffering from genetic diseases that are not suitable for reproduction as stipulated in the law on maternal and child health care; (3) severe endometriosis, adenomyosis, and immune infertility; (4) untreated hydrosalpinx; (5) congenital or acquired abnormal uterine development and other serious reproductive organ malformations; (6) complicated with reproductive system tumor, thyroid dysfunction, hyperprolactinemia and other endocrine dysfunction; (7) received ovarian stimulation treatment or OCP in recent 3 months; (8) no previous history of ovarian and other gynecological operations; (9) male factors (oligoweak teratozoospermia, obstructive azozoospermia, occult spermatozoospermia, etc.); (10) and other contraindications of assisted reproductive technology.

Design outcomes

Primary

MeasureTime frame
Obtain the number of follicles;

Countries

China

Contacts

Public ContactSun Zhengao
sunzhengao77@163.com+86 13708938621

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026