normal tension glaucoma
Conditions
Interventions
Sponsors
China Academy of Chinese Medical Sciences Eye Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: Part one inclusion criteria: Inclusion criteria for Normal control group: 1. the best corrected visual acuity (BCVA) > 0.8; 2. IOP <21 mmHg; 3. The eyeground is normal, C/D is normal. OCT shows normal RNFL thickness and normal visual field; 4. Aged 20 and 75 years. Inclusion criteria for HTG group: 1. meet the diagnostic criteria; 2. Aged between 20 and 75 years; Inclusion criteria of NTG group: 1. meet the diagnostic criteria and the TCM Syndrome Diagnostic Criteria; 2. Ages between 20 and 75 years; 3. After lowering intraocular pressure drug therapy, intraocular pressure stabilized below 15mmHg for more than 2 months. Part two inclusion criteria: 1. meet the diagnostic criteria and the TCM Syndrome Diagnostic Criteria; 2. Ages between 20 and 75 years; 3. After lowering intraocular pressure drug therapy, intraocular pressure stabilized below 15mmHg for more than 2 months.
Exclusion criteria
Exclusion criteria: Part one exclusion criteria: Exclusion criteria for control group: 1. family history of glaucoma; 2. diopter greater than + 3.00d or less than -8.00d; 3. patients with serious systemic diseases such as heart failure, liver and kidney dysfunctions, gastric and duodenal ulcers, diabetes mellitus and malignant hypertension. Serum creatinine > 2 times upper limit of normal value (ULN); Serum glutamine transaminase > 3 times ULN; 4. History of eye surgery or trauma; 5. Mental illness or anxiety, depression and other abnormal psychological state and malignant tumors; 6. Pregnant or nursing women; 7. Failing to follow doctor's advice and cooperate with relevant examinations. Exclusion criteria for NTG and HTG group: 1. Fixation loss > 20%; 2. Diopter between + 3.00d and -8.00d; 3. The false-positive or false-negative rate of visual field tested by Humphrey is greater than 33; 4. Patients with malignant tumors; 5. History of eye surgery or trauma; 6. In the past 1 month, have used traditional Chinese medicine or western medicine of vasodilator and neuroprotective drugs; 7. Suspicious or definite allergy to the study drug; 8. Serum creatinine > 2 ULN; 9. Serum glutamine transaminase > 3 ULN; 10. History of eye surgery or trauma; 11. Patients with heart Yang deficiency syndrome are mainly manifested by chest tightness and chest pain, palpitations and cold sweat, and aversion to cold limbs; 12. Mental illness or anxiety, depression and other abnormal psychological state and malignant tumors; 13. Participated in other clinical trials in the last 3 months; 14. Pregnant or nursing women; 15. Failing to follow doctor's advice and cooperate with relevant examinations. Part two exclusion criteria: Exclusion criteria for NTG and HTG group: 1. Fixation loss > 20%; 2. Diopter between + 3.00d and -8.00d; 3. The false-positive or false-negative rate of visual field tested by Humphrey is greater than 33; 4. Patients with malignant tumors; 5. History of eye surgery or trauma; 6. In the past 1 month, have used traditional Chinese medicine or western medicine of vasodilator and neuroprotective drugs; 7. Suspicious or definite allergy to the study drug; 8. Serum creatinine > 2 ULN; 9. Serum glutamine transaminase > 3 ULN; 10. History of eye surgery or trauma; 11. Patients with heart Yang deficiency syndrome are mainly manifested by chest tightness and chest pain, palpitations and cold sweat, and aversion to cold limbs; 12. Mental illness or anxiety, depression and other abnormal psychological state and malignant tumors; 13. Participated in other clinical trials in the last 3 months; 14. Pregnant or nursing women; 15. Failing to follow doctor's advice and cooperate with relevant examinations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual field;optic disc blood flow;Angle of loss of optic nerve fiber layer;vision;upstream blood supply of eye;Thickness of optic nerve fiber layer; | — |
Countries
China
Contacts
Public ContactWenbo Hou
China Academy of Chinese Medical Sciences Eye Hospital
Outcome results
None listed