Clinical study for integrated traditional Chinese and western medicine in preventing and treating premature ovarian insufficiency

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ITMCTR

Registry ID

ITMCTR1900002780

Enrollment

Unknown

Registered

2019-11-24

Start date

2016-01-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary ovarian insufficient

Interventions

Experimental group 2:The combination of Wubiefanchun oral liquid and estrogen and progesterone continued

The control group:Estrogen and progesterone continued

Experimental group 1:Wubiefanchun oral liquid

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Women of reproductive age between 20 and 40 years old who meet the diagnostic criteria of POI; 2. No steroids within 3 months before enrollment; 3. With good compliance, agreed to enter this study and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. POI caused by bilateral or unilateral ovariectomy. 2. Complicated with acute infectious diseases, cardiovascular diseases, renal diseases, liver diseases, hematopoietic diseases and other serious primary diseases. 3. Mental patients or those who cannot give full informed consent due to mental and behavioral disorders. 4. Allergic constitution or allergy to multiple drugs.

Design outcomes

Primary

Measure	Time frame
estradiol;Clinical pregnancy rate;Inhibin B;Luteinizing hormone;Follicle-stimulating hormone;anti-Mullerian hormone;	—

Secondary

Measure	Time frame
Ovarian reserve;Ovarian blood flow;Kupperman modified scoring method;Ovarian volume;	—

Countries

China

Contacts

Public ContactYong Tan

13951942495@163.com+86 13951942495

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026