Hand-foot Syndrome
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female patients, age > 18 years; 2. Patients receiving MKIs for any malignancy; 3. Grade II hand-foot syndrome according to NCI-CTC 5.0 standard; 4. KPS > 60, life expectancy >=3 months; 5. The functional level of major organs met the following criteria: 1) ANC (> 1.5 *10^9/L), PLT (> 80 *10^9/L), Hb (> 90 g/L); 2) TBIL 50 ml/min) (Cockcroft-Gault formula); 6. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Pre-existing dermopathy or drug allergy; 2. Concomitant administration of drugs that can cause HFS eg capecitabine, docetaxel, liposomal doxorubicin, etc. in four weeks; 3. Administration of drugs eg non-steroidal anti-inflammatory drugs and opioid analgesics, etc. confounding assessment of HFS; 4. Uncontrolled infections and metabolic diseases; 5. Coagulation disorders, known bleeding tendency or thrombophilia; 6. The investigators consider the patients are not suitable for this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrence rate;the change in hand-foot syndrome classification; | — |
Secondary
| Measure | Time frame |
|---|---|
| safety;tthe quality of life score; | — |
Countries
China
Contacts
Public ContactQijin Shu
Outcome results
None listed