atherosclerosis and blood-lipid metabolic disorder
Conditions
Interventions
Sponsors
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 25-65 years old, male or female; 2. TCM Syndrome differentiation is phlegm stasis; 3. Meeting the diagnostic criteria of atherosclerosis and blood-lipid metabolic disorder; 4. Patients with carotid intima-media thickness (IMT)>=1.0mm or visible plaque and carotid artery stenosis 20 cigarettes per day), obesity (BMI >28), hyperlipidemia and family history; 6. The basic principle of freely given informed consent for all subjects.
Exclusion criteria
Exclusion criteria: 1. Patients with chest pain, dizziness and headache due to cardio-cerebrovascular diseases, such as unstable angina, myocardial infarction, etc. or caused by severe neurosis, menopausal syndrome, other chest diseases and craniocerebral lesions, such as vasculogenic stroke, etc.; 2. Severe liver and kidney function damage, with alanine aminotransferase> 3 times of the upper limit of normal, or serum creatinine was high than the upper limit; 3. Combined with major systemic diseases such as the nervous system, and immune system, or poorly controlled chronic diseases such as hypertension and diabetes; 4. Those who have complicated accompanying syndromes, including deficiency of 'qi' and 'yi', 'zhong-qi sinking' or 'hyperactivity of liver yang'; 5. Allergy constitution; 6. Women of child-bearing age who are in pregnancy or lactation; 7. Patients who participated in other drug clinical trials in the past 1 months; 8. Mental disorders who failure to correctly express wishes or communicate; 9. Drug abusers or addicts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum IMT of anterior and posterior walls of carotid artery;The syndrome scorings of the phlegm stasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum plaque area of short and long axis of carotid artery;vascular endothelial function;The four methods of diagnosis;Blood biochemistry;Carotid stenosis rate or vessel diameter; | — |
Countries
China
Contacts
Public ContactXiaochang Ma
Outcome results
None listed