Sepsis-induced myopathy
Conditions
Interventions
control group:basic treatment
Sponsors
Department of Intensive Care Unit, the First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 85 years old; 2. Meet the criteria of Sepsis-320which define sepsis as infection + SOFA >=2 points within the first 24 hour; 3. The first time admitted to ICU and expect to survive within the first 48 hours; 4. Informed consent signed by the patient or immediate family member (next to kin); 5. The Rectus Femoris cross-sectional area (RFcsa) decreased more than 9.24%21 after ICU admission; 6. Survival within ICU stay.
Exclusion criteria
Exclusion criteria: 1. A confirmed positive result of pregnancy or urine beta-HCG test; 2. The questionnaire(MRC-SS/FIM/consent form) could not be completed due to cognitive abnormalities; 3. A newly diagnosed primary neuromuscular disease when admitted to the hospital; 4. Patients who have leg amputationpelvic/femoral fractures or knee/hip replacement that could not complete the measure of RFcsa; 5. Malnutrition (BMI less than 18.5 kg/m2) or cachexia; 6. Patients with metastatic tumors (PD) or ongoing chemotherapy; 7. Patients with cardiorespiratory arrest or imminent death 8. Patients with long-term corticoid treatment; 9. Can't walk independently before sepsis onset; 10. ICU length of stay <7 days; 11.Sepsis has been onset more than 5 days before ICU admission; 12. Therapy withdrawal and consent refusal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| expression levels of serum myostatin;Incidence of Time to Event;rectus femoris cross-sectional area;MRC-SS score;Functional Independence Measure; | — |
Secondary
| Measure | Time frame |
|---|---|
| case of re-admission of hospital;times of re-entered the ICU;days of hospital stay;duration of invasive/non-invasive mechanical ventilation;ICU maintain days;case of re-entered the ICU; | — |
Countries
China
Contacts
Public ContactChen Wei-Tao
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed