Refractory cirrhotic ascite
Conditions
Interventions
Sponsors
Second Department of Hepatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Western medicine standard reference guidelines for diagnosis and treatment of cirrhosis and related complications of hepatology branch of the Chinese medical association (2017 edition): (1) decompensated cirrhosis (child-pugh grade B/C). (2) obvious signs of abnormal liver function and decompensation, such as serum albumin 35 micron /L; Or elevated ALT and AST;Or prothrombin activity <60%; The patient has ascites. (3) imaging diagnosis showed that the liver surface was obviously uneven, zigzag or wavy, the liver edge became blunt, the echo of liver parenchyma was uneven and enhanced, and it was nodular, the inner diameter of portal vein and splenic portal vein was widened, the blood vessels in the liver were not clear, and the liquid dark area was visible in the abdominal cavity. (4) large diuretic drugs (160mg/d in whelk and 80mg/d in furfurmi) were treated for at least 1 week or intermittent therapeutic ascites (4000-5000ml/ time) combined with albumin (20-40g/ time/day) for ascites for 2 weeks without any response to treatment;Difficult to control diuretic drug - related complications or adverse reactions. 2. TCM standard reference 2017 cirrhosis ascites medical diagnosis and treatment Zhuangjie consensus opinion, in line with the Chinese medicine "bulging" diagnostic criteria, that is, abdominal fullness, short urine, and even abdomen as a drum, skin color pale, vein exposure as the main performance. The syndrome type conforms to the syndrome of spleen and kidney yang deficiency. Main symptoms: (1) abdominal fullness, shape like frog belly; (2) abdominal distension early light weight; (3) limb cold; secondary symptoms: (1) complexion white; (2) limb edema; (3) waist and knees soft; (4) cold pain in the abdomen. Diagnosis: 2 cases with major symptoms plus 2 minor cases, or 1 case with major symptoms plus 3 minor symptoms.
Exclusion criteria
Exclusion criteria: Exclusion criteria are those that do not meet any of the inclusion criteria; patients with severe cardiovascular, pulmonary, renal, or neurological diseases and severe primary hematological diseases, as well as patients with mental illness, tumors (hepatic tumors only exclude concurrent ascites); renal insufficiency Diabetes patients with uncontrolled blood sugar; pregnant and lactating women. Liver cirrhosis complicated with upper gastrointestinal bleeding, hepatic encephalopathy, and patients with hepatorenal syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abdominal circumference;Ascites volume;body weight; | — |
Countries
China
Contacts
Public ContactShujuan Lei
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed