Flora disorder
Conditions
Interventions
Sponsors
The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
22 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of high exposure population: (1) Sanitation workers and traffic guides working in traffic pollution environment in Chengdu, age: 22 to 65 years old, male and female are not limited, fixed post working years >= 3 years, fixed place working time >= 8 hours; (2) there was no history of gastroenteritis in the past month; (3) no hormones and antibiotics were used in the past month; (4) no nasal spray or other probiotics (such as lactic acid bacteria, bifidobacterium, etc.) yoghurt and beverage were used in the past 3 months; (5) clinical examination of lip, throat, ear, nostril (especially anterior nostril) and neck, no lymph node enlargement, inflammation, polyp, mass, runny nose, etc; (6) no chronic constipation (defecation = 3 years, fixed place working time >= 8 hours; (2) there was no history of gastroenteritis in the past month; (3) no hormones and antibiotics were used in the past month; (4) no nasal spray or other probiotics (such as lactic acid bacteria, bifidobacterium, etc.) yoghurt and beverage were used in the past 3 months; (5) clinical examination of lip, throat, ear, nostril and neck (especially anterior nostril), no lymph node enlargement, inflammation, polyp, mass, runny nose, etc; (6) no chronic constipation (defecation < 3 times a week) and hemorrhoids.
Exclusion criteria
Exclusion criteria: (1) patients with a history of gastrointestinal surgery; (2) patients with a long history of drug use; (3) a history of smoking; (4) pregnancy and lactation; (5) those who could not understand and cooperate with the experimental process; (6) patients who had participated in other clinical trials in the past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nasal microbiota structure;gut microbiota structure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function;Follow-up record of respiratory and circulatory system diseases;GSRS;SF-36;COOP/WONCA chart; | — |
Countries
China
Contacts
Public ContactFei Wang
The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed