Henoch-Sch?nlein purpura nephritis(HSPN)
Conditions
Interventions
Healthy control group:N/A
Sponsors
Hubei University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria of study group(HSPN subjects) : 1) Aged 18-60 years; 2) In accordance with diagnostic criteria of HSPN in the Clinical Guidelines-Nephrology Section which was edited by the Chinese medical association in 2011; 3) eGFR >=60 (mL/min / 1.73 m2; the MDRD formula); 4) 24-h UTP <=3.0 g; 5) Willing to provide informed consent and complete the process required by the study. 2.Inclusion criteria of control group (healthy subjects): 1) Aged 18-60 years; 2) Routine items such as blood, urine, feces, liver and kidney functions, and blood lipids are within the normal range in medical examination reports; 3) To provide informed consent.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria of study group(HSPN subjects) : 1) Women during pregnancy or lactation; 2) Participating in interventional clinical trials 3) Patients who have been treated with glucocorticoids and immunosuppressants for the past 3 months or are being treated due to HSPN; 4) I or II type diabetes; 5) NYHA Class III or IV heart failure; 6) Viral hepatitis or cirrhosis; 7) HIV infection or AIDS; 8) Malignant tumors; 9) Have been receiving dialysis for more than 1month, and/or organ or bone marrow transplantation; 10) Have been diagnosed as polycystic kidney and other hereditary kidney diseases. 2.Exclusion criteria of control group(healthy subjects) : 1) Persons who have a history of chronic diseases such as hypertension, diabetes, coronary heart disease, hyperuricemia or hyperlipidemia; 2) Persons who have a history of genetic diseases; 3) Patients with immunological and allergic diseases; 4) Patients with malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ROR?t, Foxp3;IL-17, IL-10;Th17, Treg; | — |
Countries
China
Contacts
Public ContactXue Xue
Hubei University of Traditional Chinese Medicine
Outcome results
None listed