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A randomized, single-blind, cross-controlled study for the effects of acute cold exposure on blood pressure and angiotensin II levels in humans

A randomized, single-blind, cross-controlled study for the effects of acute cold exposure on blood pressure and angiotensin II levels in humans

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR1900002524
Enrollment
Unknown
Registered
2019-08-14
Start date
2019-08-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension, hyperlipidemia

Interventions

Sponsors

Dongzhimen Hospital, Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Aged between 18 and 65 years, regardless of gender; (2) The body mass index is between 18.5-23.9kg/m2; (3) No abnormal blood pressure (systolic blood pressure <120mmHg, diastolic blood pressure <80mmHg); (4) Did not take any medicine for nearly 4 weeks; (5) There is no major disease in the past; (6) Subjects gave informed consent and signed informed consent.

Exclusion criteria

Exclusion criteria: (1) Patients with hypertension; (2) Those with previous history of hyperlipidemia and cardiovascular and cerebrovascular diseases; (3) Active ulcers and bleeding tendency, long-term use of anticoagulant, antiplatelet drugs; (4) Those who are taking antihypertensive and lipid-lowering drugs; (5) Those with severe heart, lung, liver and kidney dysfunction and nervous system diseases; (6) Other diseases or mental illnesses that the investigator believes may limit efficacy evaluation or patient follow-up; (7) Patients who have participated in other drug clinical trials in the past 4 weeks.

Design outcomes

Primary

MeasureTime frame
Blood pressure;Renin;Angiotensin II;

Secondary

MeasureTime frame
Fibrinogen;Triglyceride;Total cholesterol;Fasting blood sugar;Partial thromboplastin time;Thrombin time;Low density lipoprotein cholesterol;Prothrombin time;Transcriptomics;High density lipoprotein cholesterol;Platelet function test;Genomics;

Countries

China

Contacts

Public ContactShengxian Wu

Dongzhimen Hospital, Beijing University of Chinese Medicine

wushx@sina.com+86 13501382919

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026