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Study for the regulation mechanism of acupuncture on brain-gut in patients with migraine

Study for the regulation mechanism of acupuncture on brain-gut in patients with migraine

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR1900002521
Enrollment
Unknown
Registered
2019-08-13
Start date
2019-07-31
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

migraine without aura

Interventions

healthy control group:None
Treatment group:acupuncture

Sponsors

Chengdu University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Right hand; aged between 18-55 years, gender is not limited; 2. Education time >= 6 years; 3. Meet the above-mentioned IHS diagnostic criteria for aura without migraine; 4. There is a history of migraine for more than 1 year. The migraine first started before the age of 50. In the past 1 month and the baseline period, the average headache occurred 2-6 times per month; 5. BAI standard scores is less than 36 points, and BDI standard scores is less than 21 points; 6. The patient signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of head trauma, secondary headache, tension headache, intermittent headache, cluster headache and cardiovascular disease, digestive system diseases; 2. Those who have experienced major bowel resection or major gastrointestinal surgery in the past; 3. Mental patients, susceptible to infection and bleeding, allergies; 4. Pregnant women and lactating women; 5. Can not understand or record the headache diary; 6. Suffering from moderate constipation and diarrhea in the past 3 months; 7. In the past 1 month, he received medical treatment for cholecystitis, peptic ulcer, urinary tract infection, acute pyelonephritis, cystitis; 8. Antibiotics have been used in the past 3 months for 3 days or more; or have long-term use of drugs such as analgesics; 9. Received acupuncture or other preventive treatment in the past 3 months; 10. There are metal implants in the body, and other MRI examination contrabands such as claustrophobia; 11. In the MRI scan, severe head anatomical structures were found to be asymmetric or have clear lesions; 12. Patient has participated in similar researchers within 3 months.

Design outcomes

Primary

MeasureTime frame
HIT-6;GSRS;headche diary;Intestinal flora data collection and processing;fMRI;SF-MPQ;

Secondary

MeasureTime frame
MMSE;BDI;SF-36;BAI;

Countries

China

Contacts

Public ContactLing Zhao

Chengdu University of Traditional Chinese Medicine

ling94@163.com+86 13568801429

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026