Total knee arthroplasty
Conditions
Interventions
group 1:Intravenous infusion of 1g of tranexamic acid + 100 ml 3 hours after surgery, intravenous infusion of 100 ml of normal saline 6 and 12 hours after surgery.
group 2:Intravenous infusion of 1g of tranexamic acid + 100 ml of normal saline at 3, 6, and 12 hours after surgery
Sponsors
Guanghua Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed as rheumatoid arthritis according to the "Classification of Rheumatoid Arthritis" revised by the American College of Rheumatology in 1978 and the classification of rheumatoid arthritis by the American College of Rheumatology and the European Union of Rheumatology in 2010. Kellgren-LawrenceX line is graded III or IV; 2. Aged 50-75 years; 3. Initial unilateral TKA surgery; 4. Perioperative TXA antifibrinolytic therapy; 5. Preoperative hemoglobin, The coagulation function is normal.
Exclusion criteria
Exclusion criteria: 1. With severe cardiovascular disease (such as myocardial infarction, atrial fibrillation, angina pectoris, heart failure, etc.), cerebrovascular disease (cerebral infarction, brain Bleeding, etc., need long-term oral anticoagulant drugs (such as aspirin, warfarin, clopidogrel, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin; | — |
Countries
China
Contacts
Public ContactXiao Lianbo
Guanghua Hospital, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed