Premature ovarian insufficiency
Conditions
Interventions
healthy control group:no
Sponsors
Jiangsu Provincial Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: The study will enroll patients with a diagnosis of POI who meets the following inclusion criteria: (1) patients meeting the ESHRE Guideline diagnostic criteria for POI, right-handed; (2) women between the ages of 18 and 40 years; (3) and no acupuncture therapy within 2 months prior to study recruitment; (4) sign the informed consent form and willing to participate in the study; Patients meeting the following criteria will be selected as study volunteers: (1) right-handed women between the ages of 18 and 40, age matched with POI patients; (2) good health, no genetic history of familial psychosis, no claustrophobia; (3) no metal substances in the body that affect functional magnetic resonance examination; (4) not in pregnancy, postpartum lactation; (5) sign the informed consent form and volunteer to participate in the study.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria will be excluded from the study: 1. abnormal development of congenital reproductive organs, or uterus, bilateral ovarian or bilateral salpingectomy, combined with severe primary diseases such as cardiovascular, renal, hepatic and hematopoietic systems; 2. endocrine diseases such as polycystic ovary syndrome, hyperprolactinemia, hyperandrogenism, hypothyroidism, and chronic adrenal insufficiency affect ovulation; 3. install a pacemaker, metal allergy or severe fear of the needle, claustrophobia; 4. mental or behavioral disorders that do not match the completion of clinical observations; 5. patients who are likely to be lost to follow-up according to the judgment of the investigator, such as patients whose work environment changes frequently, whose living environment is unstable; 6. who are participating in other drug clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the hypothalamic functional connectivity imaging data obtained by fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy;Self-rating anxiety scale;Follicle stimulating hormone;prolactin;Testosterone;Antral follicle count;kupperman;Anti-müllerian hormone;Menstrual conditions;Estradiol;Luteinizing hormone;Progesterone; | — |
Countries
China
Contacts
Public ContactJianhua Sun
Jiangsu Provincial Traditional Chinese Medicine Hospital
Outcome results
None listed