Cancer Cachexia
Conditions
Interventions
Sponsors
Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 subjects are able to understand and comply with the parameters listed in the protocol and must sign informed consent approved by the independent ethics committee (IEC)/institutional verification committee (IRB) before initiating any screening or study specific procedures; 2 subjects must be adults aged = 18 years; 3 patients diagnosed with non-small cell lung cancer by imaging and histopathology and/or cytology; 4 > 1 grade a hospitals were diagnosed as stage iiiib -IV non-small cell lung cancer; 5 according to the 2011 Lancet Oncology consensus on the diagnosis and staging of cancer cachcachia, patients with body weight loss of >5% or BMI 2% within 6 months, or those with limb muscle index consistent with oligomyopathy (male 2%, which was considered as the onset of cachcachia. 6 according to RECIST version 1.1 tumor efficacy evaluation criteria, the subject's CT scan at least one measurable lesion was suggested in one hospital. 7 women and men of reproductive age must agree to use appropriate contraceptives before they are enrolled in the study, during the study and during follow-up after completion of the study.Women of reproductive age must have a negative urine pregnancy test within 7 days prior to the start of the study and/or postmenopausal women must be in menopause for at least 12 months before they can be considered infertile.
Exclusion criteria
Exclusion criteria: 1 secondary cachexia of subjects with malignant intestinal obstruction; 2 according to the NCI common adverse event evaluation criteria (NCI CTCAE), the subjects had encephalopathy above grade 2; 3 subjects' left ventricular ejection fraction <50%; 4 diseases other than clinically significant uncontrolled tumors that affect patient survival; 5 severe heart, liver and kidney diseases, diabetes mellitus, rheumatoid arthritis, and chronic obstructive pulmonary disease; 6 complicated with diseases of the blood system; 7 female subjects during pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Life qulity score;Muscle mass;Weight;Muscle mass; | — |
Secondary
| Measure | Time frame |
|---|---|
| Arm muscle circumference;Tumor seize;CRP;OVerall survice;ALB;Peripheral blood lymphocyte T cells; | — |
Countries
China
Contacts
Public ContactZhou Xutao
Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine
Outcome results
None listed