Ovarian dysfunction
Conditions
Interventions
Sponsors
Department of gynecology, Fangcun Branch of Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: (1) aged 18-39 years; (2) iatrogenic ovarian reserve function decreased after the operation of ovarian endometriosis (removal of cysts, unilateral adnexectomy, and intervention); (3) decreased ovarian reserve function: AMH was lower than the lower limit of the reference range of this age group (referring to the AMH test of patients, the standard of our hospital was: 20-24 years old: 1.52ng/ml, 25-29 years old: 1.2ng/ml, 30-34 years old: 0.711ng/ml, 36-39 years old: 0.405ng/ml);The follicular count of basal sinus was less than 5 at the 2nd to 5th day of menstruation. The basic FSH value on the 2-5 days of menstruation was greater than 10IU/L. The basic E2 value on the 2-5 days of menstruation was greater than 80pg/ml. Any one of the above four indicators can be included; (4) normal menstruation before operation.Show menstruation is normal or abnormal, but menstruation closes time 3 months less than; (5) TCM syndrome differentiation belongs to kidney deficiency and blood stasis; (6) informed consent.
Exclusion criteria
Exclusion criteria: (1) use hormones at present or within 3 months before enrollment; (2) irregular menstruation before operation. Menstrual arrested over 3 months; (3) congenital gonadal hypoplasia; With a history of autoimmune diseases, pelvic infectious diseases, mumps, etc.; (4) polycystic ovary syndrome, hyperprolactinemia, dysfunctional uterine bleeding, hypogonadotropin, hypothyroidism and other endocrine diseases (disorders); (5) surgery history for other adnexas; (6) With a history of using reproductive toxic drugs, chemotherapy drugs and radiotherapy; (7) suspected genetic factors of ovarian decline; (8) pregnant or lactating women; (9) people with bad living habits (such as frequent smoking, excessive drinking, frequent hair coloring, excessive weight loss, etc.); (10) patients with severe mental illness; (11) participated in other clinical trials in the past 3 months; (12) bilateral adnexectomy due to Chocolate cyst; Chocolate cyst recurrence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| menstrual cycle;Ovulation;Anti mullerian canal hor;Assessment of menstrual volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Luteinizing Hormone;Endometriosis quality of life scale (ehp-5);Sinus follicular count;oestrogen;Follicle-Stimulating Hormone;rate of pregnancy; | — |
Countries
China
Contacts
Public ContactWang Yongxia
Department of gynecology, Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed