MRC Multicentre randomised controlled trial of cognitive behaviour therapy in bipolar affective disorder

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99884475

Enrollment

220

Registered

2000-10-23

Start date

1999-07-01

Completion date

Unknown

Last updated

2018-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bipolar affective disorder Mental and Behavioural Disorders Bipolar affective disorder

Interventions

1. One group receiving cognitive behaviour therapy as well as treatment as usual 2. One group receiving only treatment as usual

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or more 2. Two or more episodes 3. Last episode in previous 12 months 4. Currently/last six months in contact with mental health 5. Currently asymptomatic, depression, hypomania

Exclusion criteria

Exclusion criteria: 1. Cannot engage/ rapid cycling bipolar disorder (more than or equal to four episodes per year) 2. Bipolar disorder secondary to organic cause 3. Mental disorder primarily alcohol or drug related 4. Severe borderline personality disorder 5. Receiving systematic psychological treatment for bipolar disorder 6. Unable to read/write English 7. Unable to give informed consent 8. If the patients referred to the study knew the therapist when the therapist worked in a previous capacity, (e.g. as a community psychiatric nurse in a community mental health team looking after the patient), the patient would not be entered into the study

Design outcomes

Primary

Measure	Time frame
1. Recurrence of an episode of illness of sufficient severity to reach the Diagnostic and Statistical Manual of mental disorders fourth edition (DSM-IV) criteria for major depressive episode, manic episode or mixed episode, based on the Structured Clinical Interview (SCID)instrument 2. A longitudinal severity rating of overall symptom levels for each week since last interview (two months) based on the Longitudinal Interval Follow-up Evaluation (LIFE-II) 3. Total costs - data on all services received will be obtained using the Client/Service Receipt Inventory (CSRI; Beecham and Knapp 1992) to cover first the year prior to study entry and then every six months until the end of the follow-up period	—

Measure

Time frame

1. Recurrence of an episode of illness of sufficient severity to reach the Diagnostic and Statistical Manual of mental disorders fourth edition (DSM-IV) criteria for major depressive episode, manic episode or mixed episode, based on the Structured Clinical Interview (SCID)instrument 2. A longitudinal severity rating of overall symptom levels for each week since last interview (two months) based on the Longitudinal Interval Follow-up Evaluation (LIFE-II) 3. Total costs - data on all services received will be obtained using the Client/Service Receipt Inventory (CSRI; Beecham and Knapp 1992) to cover first the year prior to study entry and then every six months until the end of the follow-up period

—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026