Doxycycline and dexamethasone as effective topical treatments for blepharitis

Doxycycline and dexamethasone as effective topical treatments for blepharitis: a phase IV open randomised controlled therapeutic equivalence trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99872501

Enrollment

Registered

2008-12-23

Start date

2009-02-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blepharitis Eye Diseases Other inflammation of eyelid

Interventions

Current interventions as of 19/03/2009: Group 1: topical doxycycline 0.05% and topical dexamethasone 0.05% (the two drugs mixed into a single ointment) to be applied four times a day for four days, th

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Both males and females, aged older than 18 years 2. No other topical treatments 3. Diagnosis of blepharitis

Exclusion criteria

Exclusion criteria: Does not meet the inclusion criteria

Design outcomes

Primary

Measure	Time frame
Symptoms assessed with a questionnaire (with a numerical scale): improvement of comfort, assessed before first treatment (baseline) and between 1 and 7 days after the end of treatment.	—

Secondary

Measure	Time frame
1. Presence or absence of conjunctival infection before and after treatment 2. Safety of topical doxycycline compared with oral doxycycline Duration of follow-up: 16 days (updated 19/03/2009; previously 20 days)	—

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026