Reducing fatigue in Long COVID-19: A feasibility study of a self-help intervention to reduce fatigue-related symptoms among patients in general practice

In people with Long COVID related fatigue, is there a difference between participants using self-help lymphatic drainage vs. no intervention on fatigue (assessed using Chalder Fatigue Questionnaire (CFQ) score) at 12 weeks?

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99840264

Enrollment

100

Registered

2022-08-09

Start date

2022-08-01

Completion date

Unknown

Last updated

2023-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatigue symptoms following Long COVID Infections and Infestations

Interventions

Following consent over the telephone by one of our research practitioners, participants will be randomised into the trial using sealed envelope (TM) 1:1 intervention to wait-list control. Randomisatio

patient instructions and online video link, a long handled massager and massage oil, hot water bottle and gel pack for contract bathing and a tick sheet to monitor recommended exercises, Wait-list con

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult aged 18 years or over 2. Tested positive for COVID (between July 2020 and February 2022) 3. Scored of 4 or more on Chalder Fatigue Questionnaire scored bimodally (0,0,1,1)

Exclusion criteria

Exclusion criteria: 1. Less than 18 years 2. Current or previous ME/CFS diagnosis 3. Current end-stage heart failure, cancer, sleep apnoea (or other major sleep disorders) 4. Major mental health diagnoses ( eg. schizophrenia) 5. Pregnant and lactating women 6. Care home residents 7. Dementia

Design outcomes

Primary

Measure	Time frame
1. The recruitment rate into our Phase 2 intervention will be recorded as the number of eligible participants who consented to participate in the study over the 4 month recruitment period. 2. The attrition rate in our Phase 2 intervention will be recorded as the number of eligible participants who consented to participate in the study but had not completed final 24 week follow-up measures.	—

Secondary

Measure	Time frame
1. Fatigue is measured using Chalder Fatigue Questionnaire (with participants completing online questionnaire using scoring 0,1,2,3) at 0, 12 and 24 weeks. 2. Physical functioning is measured using SF-12 at 0,12 and 24 weeks (online questionnaire) at 0, 12 and 24 weeks. 3. Quality of life is measured using EQ-5D at 0,12 and 24 weeks (online questionnaire) at 0, 12 and 24 weeks.	—

Countries

England, United Kingdom

Contacts

Public ContactLisa Riste

lisa.riste@manchester.ac.uk+44 7903133719

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026