The interrelationships between changes in the metabolic state and homeostasis of the bone and injection of a new substance during orthodontic tooth movement

Evaluation of the efficacy of locally injected zoledronic acid in increasing the anchorage during en-masse retraction of the maxillary anterior teeth: a randomized controlled clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99776766

Enrollment

Registered

2024-05-07

Start date

2023-04-01

Completion date

Unknown

Last updated

2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skeletal class II and moderate maxillary protrusion Musculoskeletal Diseases

Interventions

Patients will be randomly allocated into two groups using Microsoft® Excel electronic randomization: Group 1: Experimental group: the dental arch will first be aligned with wires 0.12, 0.14, 0.16, 16.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patient who has a second class II as light to medium with 4<ANB<8 2. In the vertical plane, a natural or slight vertical growth pattern 3. Moderate anchorage, where the molar and canine relationships are cusp to cusp 4. The mandibular dental arch is well aligned or slightly crowed and does not require extraction treatment 5. A patient with good oral health and healthy periodontal tissue 6. A patient who does not take any medications 7. A patient who has not undergone previous orthodontic treatment

Exclusion criteria

Exclusion criteria: 1. Patients who have a severe structural defect in the sagittal plane 2. Patients who have a severe horizontal or vertical growth pattern 3. The patient who has moderate to severe crowding in the lower dental arch requires extraction to treat it 4. Patients with general diseases or craniofacial syndromes 5. Pregnant or breastfeeding

Design outcomes

Primary

Measure	Time frame
1. The amount of slippage of the upper first molars mesially during retraction 2. The inclination of the axes of the upper first molars 3. Rotation of maxillary first molars 4. The height of the alveolar bone in the injection area 5. The thickness of the alveolar bone in the injection area 6. Root resorption of maxillary first molars Measured using cone beam computed tomography (CBCT) before the start of orthodontic treatment and after the end of the mass retraction	—

Measure

Time frame

1. The amount of slippage of the upper first molars mesially during retraction 2. The inclination of the axes of the upper first molars 3. Rotation of maxillary first molars 4. The height of the alveolar bone in the injection area 5. The thickness of the alveolar bone in the injection area 6. Root resorption of maxillary first molars Measured using cone beam computed tomography (CBCT) before the start of orthodontic treatment and after the end of the mass retraction

—

Secondary

Measure	Time frame
Pain and discomfort following injection measured using the visual analogue score (VAS) at baseline, 1, 3, and 7 days	—

Countries

Syria

Contacts

Public ContactFryal Rahme

fryal3.rahme@damascusuniversity.edu.sy+963 (0)99492798

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026