The effect of gamma-tocopherol supplementation on gamma-tocopherol status, antioxidant capacity and nitrosative stress in apparently healthy smokers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99748080

Enrollment

Registered

2008-02-21

Start date

2006-03-31

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular risk Circulatory System Cardiovascular risk

Interventions

Oral supplementation of 100 mg of gamma-tocopherol or a placebo. Supplementation is provided for 6 months. There is no further follow-up after the post-intervention samples are collected.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Consenting adult men and women 2. Smoke five or more cigarettes per day 3. Between 18 and 50 years of age 4. In general good health

Exclusion criteria

Exclusion criteria: 1. Non-smokers 2. Pregnancy 3. Diagnosed chronic disease 4. Those who take vitamin E containing supplements or prescribed medication

Design outcomes

Primary

Measure	Time frame
1. Tocopherol concentrations 2. Selenium concentrations 3. Inflammation markers All primary outcome measures are assessed when samples are collected at baseline, month 3 and month 6.	—

Secondary

Measure	Time frame
1. Body composition measurements 2. Immune markers All secondary outcome measures are assessed at baseline and month 6.	—

Countries

Ireland, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026