Effect of treatment with low-dose hydrocortisone on cirrhotic patients presenting with septic shock to the intensive care unit

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99675218

Enrollment

150

Registered

2005-09-08

Start date

2004-04-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock in cirrhotics Infections and Infestations Septicaemia

Interventions

This a placebo-controlled double blind randomized controlled trial. The intervention is to give hydrocortisone versus palcebo. Ethic Committee approval date: 26/10/2003.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Cirrhotic patients admitted to the Intensive Care Unit with septic shock

Exclusion criteria

Exclusion criteria: 1. Pure hypovolemia 2. Hemorrhagic shock 3. Known adrenal insufficiency 4. Prior steroid use 5. Do not resuscitate (DNR) order 6. Patients in terminal condition 7. Contraindication to steroids 8. Refused consent 9. Post-cardiac arrest 10. Patient unexpected to survive 24 hours

Design outcomes

Primary

Measure	Time frame
28-all cause mortality	—

Secondary

Measure	Time frame
1. Intensive care unit (ICU) mortality 2. Hospital mortality 3. Reversal of shock 4. Vasopressor-free days 5. Mechanical ventilation-free days 6. Renal replacement free days 7. ICU length of stay 8. ICU acquired infection 9. Requirment and duration of vasopressor therapy	—

Countries

Saudi Arabia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 30, 2026