Testosterone therapy as an adjunct to exercise rehabilitation: effects on exercise capacity, inflammatory markers and quality of life in hypogonadal males with chronic heart failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99667121

Enrollment

Registered

2006-09-13

Start date

2006-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypogonadal males with chronic heart failure Circulatory System Hypogonadal males with chronic heart failure

Interventions

Exercise alone versus exercise and adjunctive testosterone therapy.

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Ambulant males 2. Over 18 years 3. Stable chronic heart failure 4. Blood testosterone level of less than 12 nmol/l 5. Symptoms of hypogonadism

Exclusion criteria

Exclusion criteria: 1. Unstable agina 2. Recent acute myocardial infarction 3. Decompensated heart failure 4. Haemodyamically significant valvular heart disease 5. Uncontrolled hypertension 6. Renal insufficiency 7. Urologic disorders 8. Orthopedic/neurologic illness limiting the ability to exercise

Design outcomes

Primary

Measure	Time frame
Exercise capacity at the 12 week time point in relation to baseline.	—

Secondary

Measure	Time frame
1. Inflammatory markers 2. Tests of cardiac and skeletal muscle function 3. Indices of psychological health status 4. Quality of life	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026