Malaria Infections and Infestations Unspecified malaria
Conditions
Interventions
Current interventions as of 29/11/2022:
A total of 16 clusters (provincial health zones) are involved in the study
clusters were randomised to receive a different type of treated bednet by a member of LSTM staff, who will not be directly involved in the study. All houses within the eight zones allocated to group 1
within the seven zones allocated to group 2 will receive a PBO co-treated bednet. Within the remaining zone, the distribution will be mixed with one part receiving each bednet, as dictated by differen
Sponsors
Liverpool School of Tropical Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women attending first ANC appointment at a clinic that is taking part in the study and who consent to be enrolled in the study
Exclusion criteria
Exclusion criteria: 1. Young adolescents (<15 years) 2. Women presenting with symptoms of severe malaria 3. Women suffering from other illness requiring prompt treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measure as of 29/11/2022: Parasite prevalence (defined as the proportion of positive malaria rapid diagnostic tests) in pregnant women assessed at 0, 6 months, 12 months, 18 months, 24 months, and 30 months after bednet distribution _____ Previous primary outcome measure: Parasite prevalence (defined as the proportion of positive malaria rapid diagnostic tests) in pregnant women assessed at 0, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months after bednet distribution | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Frequency of molecular markers associated with insecticide resistance in the primary malaria vector mosquito (Anopheles gambiae) is measured from DNA extracted from mosquitoes collected in one half of the study clusters at 0, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months after bednet distribution 2. Mosquito abundance and parasite infection rate (with the infectious sporozoite stage) will be measured in one half of the study clusters at 0, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months after bednet distribution 3. Prevalence and intensity of phenotypic insecticide resistance, assessed using World Health Organization (WHO) tests of insecticide, in 4 study clusters at 0, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months after bednet distribution 4. Bednet durability and bio-efficacy assessed will be measured using WHO guidelines for physical assessment of the area of holes, chemical analysis of insecticide (and PBO) concentrations and capacity of the net material to kill locally-caught mosquitoes in controlled experiments in nets collected from 4 study clusters at 0, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months after bednet distribution | — |
Countries
Congo, Democratic Republic
Outcome results
None listed