Renal failure Urological and Genital Diseases
Conditions
Interventions
Each subject will have a heart tracing (ECG) performed before and after a haemodialysis session with some blood tests taken for research at the time of haemodialysis. The next day, subjects will under
Sponsors
NHS Greater Glasgow and Clyde (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients who have been treated with haemodialysis for <1 year are eligible
Exclusion criteria
Exclusion criteria: 1. Live donor transplant planned during the next 6 months 2. Predicted life expectancy <6months 3. Inability to give informed consent 4. Contraindications to MRI imaging (pacemaker, extreme claustrophobia) 5. Atrial fibrillation (makes gating of CMR images difficult)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volume of myocardial fibrosis on cardiac MRI scanning. This will be measured by MRI scanning of the heart at baseline and on a follow up MRI 6 months later. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in serum brain natriuretic peptide 2. Simple correlations will be tested between presence/volume of fibrosis and serum markers of cardiac muscle enlargements/fibrosis and features of arrhythmia on ECG (heart tracing) Measured at baseline and 6 months later | — |
Countries
United Kingdom
Outcome results
None listed