Effects of transcranial direct current stimulation (tDCS) in patients suffering from obsessive-compulsive disorder Mental and Behavioural Disorders
Conditions
Interventions
tDCS (active condition) vs. sham tDCS (control condition) will be applied in a double-blinded randomized cross-over design. tDCS in the active condition will comprise 20 minutes of anodal tDCS over th
Sponsors
Deutsche Forschungsgemeinschaft
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. MRI compatibility, age 18-65 years, right-handedness 2. OCD according to DSM-V 3. At least a score of 8 in the Y-BOCS scale 4. No additional psychopharmacological medication (e.g. antipsychotic medication) 5. No bipolar disorder, no schizophrenia, no schizo-affective disorder, no posttraumatic stres disorder, no substance abuse (apart from nicotine), no personality disorder
Exclusion criteria
Exclusion criteria: 1. Suicidality 2. Neurological disorder 3. Pregnancy 4. Inability to provide consent 5. No willingness to provide consent after information about the study 6. Medicated with benzodiazepines within the last 24 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Brain activation and connectivity measured during real tDCS and sham tDCS using functional magnetic resonance imaging (fMRI) during two response inhibition tasks. Real tDCS and sham tDCS take place 1 week apart. 2. Inhibition performance measured with two well-established inhibition tasks (Stroop task, Stop-Signal-task) at T0 (i.e., first MRI measurement timepoint) and T1 (i.e., 1 week later). | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical symptoms assessed with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) at T0 (i.e., first MRI measurement timepoint) and T1 (i.e., 1 week later) | — |
Countries
Germany
Outcome results
None listed