Breast Cancer Cancer Breast Cancer
Conditions
Interventions
1. Treatment A: Complete local excision with no further initial local or systemic therapy.
2. Treatment B: Complete local excision followed by supervoltage radiotherapy to the residual breast tissue
Sponsors
Cancer Research UK (CRUK) (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Unilateral or bilateral DCIS which is cosmetically suited to breast conservation, which has been detected as a result of attendance at a screening centre, which is without evidence of invasion, and which has been completely excised as determined by free margins on histological examination 2. Patients with similarly defined DCIS lesions, in whom the diagnosis of DCIS has been made as a result of mammograms taken following referral to a diagnostic clinic 3. Patients with Paget's disease of the nipple, lobular carcinoma in situ of the breast or atypical hyperplasia in the absence of DCIS are excluded 4. Pathologist must be able to state that the excision margins are clear, even after re-excision 5. No axillary lymph node involvement 6. Able to receive either treatment
Exclusion criteria
Exclusion criteria: 1. Involved excision margins 2. Paget's Disease 3. Nodal spread
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Local control of disease 2. Any involvement of contralateral breast 3. Overall survival and cause-specific mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
Australia, New Zealand, United Kingdom
Outcome results
None listed