Skip to content

Positive Memory Training for the treatment of depression in schizophrenia

Positive Memory Training for the treatment of depression in schizophrenia: a randomised controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN99485756
Enrollment
100
Registered
2014-03-13
Start date
2014-04-01
Completion date
Unknown
Last updated
2021-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Mental Health Research Network

Interventions

Individuals who give consent and are eligible for the study will undergo an assessment at the start and 3 months, 6 months and 9 months after the first assessment. After the initial assessment, partic

Sponsors

Berkshire Healthcare Foundation Trust (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Participants will be included if: 1. They consent and have a current DSM-IV diagnosis of schizophrenia or schizo-affective disorder 2. Present with symptoms consistent with at least a mild level of depression, as indicated by a score of 14 or above on the BDI-II 3. They will be aged between 18 and 65 4. They will be able to read and write in English to a level required to participate in a talking therapy 5. Have a fixed abode: Operationalised as having a current address (including B&B or open access hostel) 6. Evidence (e.g., from key worker) indicating that the person is more likely than not to have a reliable address throughout the 12 months study duration

Exclusion criteria

Exclusion criteria: Not be suffering from an organic disorder which is associated with psychotic symptoms or have a learning disability.

Design outcomes

Primary

MeasureTime frame
Depression: self-report, assessed through the Beck Depression Inventory-II at 3, 6 and 9 months

Secondary

MeasureTime frame
1. Schizophrenia symptoms (0, 3 and 9 months only). Assessed by clinical interview using the Positive and Negative Symptom Scale (PANSS). 2. Mood and Quality of Life. Assessed using the Generalised Anxiety Disorder Assessment (GAD7), the Work and Social Adjustment scale and the Warwick-Edinburgh Mental Well-Being Scale. 3. Self-Esteem. Measured using the Rosenberg self-esteem scale. 4. Mental Imagery (0, 3 and 9 months only). . Assessed using the Spontaneous Use of Imagery Scale. 5. Therapy Satisfaction (end of treatment only). Assessed using the newly developed measure. 6. Level of Service Use and Costs. Using a version of the Client Service Receipt Inventory (CSRI) which has been adapted for use in the current study and termed the Health Economic Questionnaire (0, 3 and 9 months). 7. Generic health-related quality of life and broader well-being of patients. EuroQol EQ-5D-5L, ICECAP-A and OxCAP-MH (0, 3, 6, 9 months). 8. Generic health-related quality of life and broader well-being of primary carers. EuroQol EQ-5D-5L and Carer Experiences Scale (CES) (0 and 9 months).

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 5, 2026