Exploring the Landscape of Optic Neuropathy and Vasculopathy: the LOVE study

Landscape of optic neuropathy and vasculopathy evolution (LOVE) study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN99411112

Enrollment

1200

Registered

2024-04-03

Start date

2017-01-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optic neuropathy in individuals with diabetes Eye Diseases

Interventions

The LOVE study is a retrospective and prospective ambispective cohort study, including individuals with and without diabetes who attend Zhongshan Ophthalmic Center (ZOC) screening. All individuals in

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Community-registered patients with diabetes 2. Individuals who live in Guangzhou for more than 6 months 3. Aged 18 years and older 4. Individuals who are capable of cooperating with ocular examinations and meeting quality standards 5. Individuals who voluntarily participate in this study 6. Individuals who do not participate in other trials or treatments aimed at preventing or delaying the onset and progression of diabetic retinopathy (DR) 7. Absence of retinal lesions, or retinal/macular lesions not meeting the positive criteria for referable DR

Exclusion criteria

Exclusion criteria: 1. Individuals who cannot cooperate with examinations

Design outcomes

Primary

Measure	Time frame
Longitudinal change of peripapillary retinal nerve fiber layer thickness measured using optical coherence tomography (OCT) in eligible participants at baseline and each follow-up visit (2 and 4 years)	—

Secondary

Measure	Time frame
1. Longitudinal change of macular ganglion cell-inner plexiform layer (GCIPL) thickness measured using optical coherence tomography (OCT) in eligible participants at baseline and each follow-up visit (2 and 4 years) 2. Longitudinal change of macular ganglion cell complex (GCC) thickness measured using OCT in eligible participants at baseline and each follow-up visit (2 and 4 years) 3. Longitudinal change of macular microcirculation measured using optical coherence tomography angiography (OCTA) in eligible participants at baseline and each follow-up visit (2 and 4 years) 4. Longitudinal change of microcirculation in optic nerve head measured using OCTA in eligible participants at baseline and each follow-up visit (2 and 4 years)	—

Measure

Time frame

1. Longitudinal change of macular ganglion cell-inner plexiform layer (GCIPL) thickness measured using optical coherence tomography (OCT) in eligible participants at baseline and each follow-up visit (2 and 4 years) 2. Longitudinal change of macular ganglion cell complex (GCC) thickness measured using OCT in eligible participants at baseline and each follow-up visit (2 and 4 years) 3. Longitudinal change of macular microcirculation measured using optical coherence tomography angiography (OCTA) in eligible participants at baseline and each follow-up visit (2 and 4 years) 4. Longitudinal change of microcirculation in optic nerve head measured using OCTA in eligible participants at baseline and each follow-up visit (2 and 4 years)

—

Countries

China

Contacts

Public ContactWei Wang

wangwei@gzzoc.com+86 (0)20 87334687

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026