Schistosoma mansoni infection Infections and Infestations Schistosomiasis (bilharziasis)
Conditions
Interventions
The study will be implemented in 75 schools of western Côte d'Ivoire. The 75 schools are randomly assigned to three study arms (25 schools per arm)
1. Schools of arm A: treated annually with praziquan
Sponsors
Swiss Tropical and Public Health Institute (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Schoolchildren, either male or female, aged 9-12 years, attending the selected schools (in each study year) 2. First-year students, either male or female, attending the selected schools (in years 1 and 5) 3. Written informed consent signed by parents or legal guardians of the schoolchildren 4. Oral assent from schoolchildren 5. At least one stool sample provided over three consecutive days from 9- to 12- years- old children each study year 6. At least one stool sample provided from first-year students in years 1 and 5
Exclusion criteria
Exclusion criteria: 1. Children not attending the selected schools 2. Children not aged 9-12 years (in years 2, 3 and 4) 3. Children not aged 9-12 years or being first-year students (in years 1 and 5) 4. No written informed consent by parents or legal guardians of schoolchildren 5. No oral assent given by schoolchildren 6. No stool sample provided (for 9- to12-year-old children in each study year; for first-year students in years 1 and 5)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As of 21/03/2016: Prevalence and intensity of S. mansoni infections in 9- to-12- year-old schoolchildren. Initial: Identification of the most cost-effective strategy that is able to reduce S. mansoni infection from moderate (10-24%) to low prevalence levels (<10%). Measured by change in prevalence and intensity of Schistosoma mansoni infection in cohorts of 9- to 12-year-old children over the four years of intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| As of 21/03/2016: 1. Prevalence and intensity of S. mansoni infections in first-year schoolchildren 2. Control of morbidity due to S. mansoni (reduction of the prevelance to <10%) in the 75 schools 3. Identification of S. mansoni risk factors 4. Mapping and prediction of the distribution S. mansoni in western Côte d'Ivoire Initial 1. Prevalence and intensity of S. mansoni infections in 9- to-12- year-old schoolchildren 2. Prevalence and intensity of S. mansoni infections in first-year schoolchildren 3. Control of morbidity due to S. mansoni (reduction of the prevelance to <10%) in the 75 schools 4. Identification of S. mansoni risk factors 5. Mapping and prediction of the distribution S. mansoni in western Côte d'Ivoire Measured by changes in force of transmission, as assessed by infection prevalence and intensity of S. mansoni in first-year students and adults. | — |
Countries
Cote d'Ivoire
Outcome results
None listed