Multiple-center clinical trial comparing surgical and conservative treatment in patients with anterior temporomandibular disc displacement without reduction

A multicenter, prospective, randomized controlled trial of surgical versus conservative treatment in patients with temporomandibular joint anterior displacement without reduction

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99353996

Enrollment

Registered

2024-03-06

Start date

2024-06-07

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior disc displacement of the temporomandibular joint without reduction Musculoskeletal Diseases

Interventions

Current interventions as of 11/03/2024: This study is a multicenter, prospective, randomized controlled trial assessing the efficacy of surgical versus conservative treatments in adult temporomandibul

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Patients with temporomandibular joint anterior disc displacement without reduction (ADDWoR) who have not previously been treated 2. Available and well-preserved clinical data 3. Adults aged 18 to 55 years old

Exclusion criteria

Exclusion criteria: 1. Presence of biased chewing habits or significant occlusal interference 2. Presence of other severe illnesses or organ dysfunction 3. Incomplete clinical data 4. Individuals under the age of 18 years

Design outcomes

Primary

Measure	Time frame
Current primary outcome measures as of 11/03/2024: 1. Morphology, volume, and position analysis of the condyle will be conducted using spiral CT scans and 3D reconstruction software. The volume changes will be compared between different time points at the beginning of treatment T0, 12 months after treatment T3, and 24 months after treatment T4. 2. Analysis of disc morphology and position using MRI scans at different time points, comparing the results using 3D reconstruction software before the start of the treatment T0, one month after treatment T1, six months after treatment T2, and 24 months postoperatively T4. Previous primary outcome measures: 1. Morphology, volume, and position analysis of the condyle will be conducted using spiral CT scans and 3D reconstruction software. The volume changes will be compared between different time points at 6, 12, and 24 months postoperatively. 2. Analysis of disc morphology and position using MRI scans at different time points, comparing the results using 3D reconstruction software at 6, 12, and 24 months postoperatively.	—

Measure

Time frame

Current primary outcome measures as of 11/03/2024: 1. Morphology, volume, and position analysis of the condyle will be conducted using spiral CT scans and 3D reconstruction software. The volume changes will be compared between different time points at the beginning of treatment T0, 12 months after treatment T3, and 24 months after treatment T4. 2. Analysis of disc morphology and position using MRI scans at different time points, comparing the results using 3D reconstruction software before the start of the treatment T0, one month after treatment T1, six months after treatment T2, and 24 months postoperatively T4. Previous primary outcome measures: 1. Morphology, volume, and position analysis of the condyle will be conducted using spiral CT scans and 3D reconstruction software. The volume changes will be compared between different time points at 6, 12, and 24 months postoperatively. 2. Analysis of disc morphology and position using MRI scans at different time points, comparing the results using 3D reconstruction software at 6, 12, and 24 months postoperatively.

—

Secondary

Measure	Time frame
Current secondary outcome measures as of 11/03/2024: Psychological state assessment using psychological scales such as General Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and PHQ-15 at T0 before the start of the treatment, 1 month after the treatment T1, 6 month after the treatment T2, 12 months after the treatment T3, and 24 months postoperatively T4. Previous secondary outcome measures: Psychological state assessment using psychological scales such as General Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and PHQ-15 at 6, 12, and 24 months postoperatively	—

Measure

Time frame

Current secondary outcome measures as of 11/03/2024: Psychological state assessment using psychological scales such as General Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and PHQ-15 at T0 before the start of the treatment, 1 month after the treatment T1, 6 month after the treatment T2, 12 months after the treatment T3, and 24 months postoperatively T4. Previous secondary outcome measures: Psychological state assessment using psychological scales such as General Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and PHQ-15 at 6, 12, and 24 months postoperatively

—

Countries

China

Contacts

Public ContactNan Jiang

dent_jn@163.com+86 (0)180 8086 3515

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Aug 9, 2026