Randomised, blinded, comparison of the respiratory depressant effects of morphine and S(+) ketamin infusions when used to provide postoperative analgesia in infants undergoing major surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN99206122

Enrollment

Registered

2005-09-30

Start date

2004-10-11

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post operative pain Surgery Post operative pain

Interventions

S(+)ketamin or morphine by direct continuous infusion.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 70 infants aged less than 60 weeks post-conceptual age undergoing elective or urgent abdominal surgery who would not be expected to require postoperative artificial ventilation.

Exclusion criteria

Exclusion criteria: 1. Patients with severe CNS abnormalities 2. Patients with severe renal or hepatic dysfunction 3. Patients with post-conceptual age of <37 weeks 4. Patients requiring respiratory support preoperatively 5. Patients receiving epidural opioids or local anaesthetic drugs 6. Patients having apnoeas or periodic breathing preoperatively

Design outcomes

Primary

Measure	Time frame
To use the total number of respiratory depression episodes measured over the first 24 hours after return to the ward following surgery as primary clinical relevant variable.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026