Acute cerebral infarction Circulatory System Acute cerebral infarction
Conditions
Interventions
Participants are randomly allocated to one of two groups.
Treatment group: Participants receive acupuncture with waking up spirit needling method
1. Acupuncture bloodletting will be conducted at acup
Sponsors
Research Office of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 30 to 80 years old with acute cerebral infarction, and their onset time is less than 7 days 2. Meet the western medicine diagnostic criterion for cerebral infarction issued by American Heart Association/American Stroke Association, AHA/ASA in 2013 3. Meet the traditional Chinese medicine diagnostic criterion developed according to the Stroke Diagnosis and Curative Effect Evaluation Standard (Draft) by State Administration of Traditional Chinese Medicine, Acute Encephalopathy Research Group 4. Diagnosis confirmed by head CT or MRI 5. Confirmed with CVR impairment by breath-holding test 6. With NIHSS score larger than or equal to 5 points, or less than or equal to 20 points, and Glasgow Coma Scale score larger than or equal to 12 points 7. Agree to participant in this trial and assign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Using antithrombotics such as Low Molecular Heparin because of some other disease 2. Carotid artery stenting 3. Serious heart, lung or kidney diseases 4. Do not coordinate the brain ultrasound examination or quantitative score evaluation due to other diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Cerebral vascular reserve (CVR) capacity is determined using the mean blood flow velocity (MFV) of the middle cerebral arteries, as measured with Transcranial Doppler (TCD) breath holding test at baseline and 2 weeks 2. Breath-holding index (BHI) is measured at baseline and 2 weeks CVR detection method: Transcranial doppler breath holding test is applied. Patients are instructed how to hold the breath, and then they practice for twice before the detection. Patients take supine position, breath peacefully for 5 minutes. Then two ultrasonic probes of TCD machine (EMS-9W, Nanjing Bang’ao Medical Apparatus Ltd. Co., Nanjing, China) are put on bilateral temporal windows with depth of 50-55 mm to measure the blood velocity of bilateral middle cerebral artery, M1. When the best blood flow signal is obtained, the probes are fixed. The mean blood flow velocity is recorded as patients in a calm state. Then patients are asked to hold breath for at least 15 seconds, and the mean blood flow velocity is recorded again. CVR = (After holding breath MFV - Before holding breath MFV)/ Before holding breath MFV×100%. CVR function is impaired if CVR is less than 20%. BHI = (After holding breath MFV- Before holding breath MFV) / Before holding breath MFV×(100/time holding breath). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Nerve function is measured using the national institutes of health stroke scale (NIHSS) at baseline, 1 week and 2 weeks 2. Performance in activities of daily living is measured using the Barthel Index at baseline, 1 week and 2 weeks | — |
Countries
China
Outcome results
None listed