Respiratory syncytial virus acute bronchiolitis Respiratory Respiratory syncytial virus acute bronchiolitis
Conditions
Interventions
Participants are randomly allocated to one of four blocks. These blocks are randomly allocated to one of two groups.
Group one (the intervention group) receive Heliox therapy (70:30) delivered throug
Sponsors
Mansoura University Children Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Infants aged from 1 month to 2 years old 2. Patients who are admitted to the pediatric high dependency unit, with RSV acute bronchiolitis diagnosed clinically confirmed by laboratory testing 3. Display the diagnostic criteria of bronchiolitis including cough, tachypnea, chest retraction, prolonged expiratory time, sibilant rhonchi, and hyperinflation of the lungs 3. Cannot maintain oxygen saturation = 93% in room air and require supplemental oxygen on admission to hospital
Exclusion criteria
Exclusion criteria: 1. No informed consent obtained 2. Require mechanical ventilation 3. Congenital heart defect that is haemodynamically significant (significant left-to-right shunting with or without pulmonary hypertension or right-to-left shunting) 4. Underlying chronic lung disease including bronchopulmonary dysplasia and previously diagnosed hyper-reactive airway diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Partial arterial pressure and partial arterial oxygen are assessed using arterial blood samples at baseline, 2 hours and 24 hours 1.1. Oxygen saturation is assessed using pulse Masimo SET pulse oximeter continuously throughout the intervention 2. Respiratory distress is measured by the Modified Wood’s Clinical Asthma Score at 2 hours and 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stay is measured by reviewing patient notes at the end of hospital stay. | — |
Countries
Kuwait
Outcome results
None listed