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Helping older adults with an overactive bladder protect their brain health by improving sleep

A comprehensive intervention study plan for cognitive vulnerability in elderly patients with overactive bladder based on sleep-lymphoid pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN98707807
Enrollment
130
Registered
2026-04-13
Start date
2024-04-22
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overactive bladder syndrome Urological and Genital Diseases

Interventions

Participants will be randomized in a 1:1 ratio to either the control group (standard behavioral management) or the intervention group (standard behavioral management plus a comprehensive mechanism-tar

Sponsors

Wuxi No.2 People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age =60 years old 2. Idiopathic OAB that meets ICS/ guidelines definitions 3. OAB symptoms persist for =3 months 4. OABSS =6 5. Nocturia =2 times per night 6. PSQI =6 7. For people with cognitive fragility but not dementia, MoCA 20 - 27 is recommended 8. Willing to complete the 24-week intervention and follow-up and sign informed consent

Exclusion criteria

Exclusion criteria: 1. Lower urinary tract symptoms (LUTS) clearly caused by neurological disorders 2. Previous diagnosis of dementia or significant functional dependence 3. Significant bladder outlet obstruction or significant residual urine 4. Organic diseases such as acute urinary infections, bladder tumors, and bladder stones 5. Uncontrolled severe depression/anxiety 6. Confirmed moderate-to-severe obstructive sleep apnea that is untreated 7. Recent use of medications that may significantly affect cognition or sleep and cannot be stabilized 8. Contraindications to MRI or inability to complete the exercise intervention

Countries

China

Contacts

Public ContactSiyi Fu
fusiyi0210@163.com+86 18967215772

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 1, 2026