Ventilation in endobronchial valve (EBV) insertion for lung volume reduction therapy (LVRT) Respiratory
Conditions
Interventions
This study will be conducted over 24 months, comprising two patient cohorts - Cohort A, COPD patients selected and planned for endobronchial valve (EBV) treatment and Cohort B, COPD patients deemed in
Sponsors
Oxford University Hospitals NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or over 2. Willing and able to give informed consent 3. Worked up for EBV therapy in the local COPD clinic Cohort A – No evidence of CV and eligible for EBV treatment MDT and patient decision for EBV therapy Cohort B – Ineligible for EBV treatment following current standard assessments MDT decision not for EBV therapy
Exclusion criteria
Exclusion criteria: 1. Pregnant, lactating or planning pregnancy during the study 2. Inability to lie flat for imaging 3. Contraindications to MRI examinations as locally determined 4. Any other reason, as determined by the study investigators, that renders the participant ineligible for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in the pattern of ventilation measured using on hyperpolarised xenon-129 MRI (HPX-MRI) in those with confirmed collateral ventilation (CV) and those treated with EBV at baseline and follow-up (6 months) | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative and/or qualitative differences of HPX-MRI findings at baseline and follow-up (6 months) | — |
Countries
England, United Kingdom
Contacts
Public ContactAvianna Laws
Outcome results
None listed