Protection against acute renal failure following cardiac surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN98672577

Enrollment

1100

Registered

2003-09-12

Start date

2006-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute renal failure during cardiopulmonary bypass surgery. Surgery Acute renal failure during cardiopulmonary bypass surgery

Interventions

1100 patients undergoing cardiac surgery with the use of CPB will be allocated randomly to one of four groups. The administration of the allocated intervention will be as follows: 1. Group 1: dopamin

Eligibility

Inclusion criteria

Inclusion criteria: Not provided at time of registration

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
1. Oliguria, defined as a urine output of less than 0.5 ml/kg/h for two consecutive hours, or less than 400 ml urine over any 24 hour period postoperatively. In addition, the need for frusemide or dopamine to maintain adequate urine output 2. Creatinine change, an increase of 50% from the baseline creatinine (i.e. a 33% reduction in Glomerular Filtration Rate [GFR]) 3. Glomerular permeability (monitored by urinary albumin excretion) 4. Renal replacement therapy 5. Death	—

Measure

Time frame

1. Oliguria, defined as a urine output of less than 0.5 ml/kg/h for two consecutive hours, or less than 400 ml urine over any 24 hour period postoperatively. In addition, the need for frusemide or dopamine to maintain adequate urine output 2. Creatinine change, an increase of 50% from the baseline creatinine (i.e. a 33% reduction in Glomerular Filtration Rate [GFR]) 3. Glomerular permeability (monitored by urinary albumin excretion) 4. Renal replacement therapy 5. Death

—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026