Does allopurinol/urate lowering by xanthine oxidase inhibition have an impact on arterial stiffness in stroke survivors?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN98638368

Enrollment

120

Registered

2006-12-13

Start date

2002-02-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke Circulatory System Stroke

Interventions

Patients were randomly allocated to receive either allopurinol 300 mg once daily or matched placebo. Baseline measurements were taken as part of the initial study and follow-up measurements were made

Eligibility

Inclusion criteria

Inclusion criteria: Stroke survivors who have a high serum urate

Exclusion criteria

Exclusion criteria: 1. Documented reaction to allopurinol 2. Persons who were incapable of giving informed consent

Design outcomes

Primary

Measure	Time frame
Correlation between arterial stiffness and urate levels.	—

Secondary

Measure	Time frame
Effect of allopurinol on arterial stiffness.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026