Carotid sinus syndrome Nervous System Diseases Carotid sinus syndrome
Conditions
Interventions
Cardiac pacemaker versus Thera rate drop responsive Medtronic Inc dual chamber pacemaker.
Sponsors
British Heart Foundation (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Added 16/02/2009: 1. Aged greater than or equal to 50 years, either sex 2. A minimum of two unexplained falls, +/- up to one syncope, in the previous 12 months 3. Mini Mental State Examination (MMSE) greater than 20/30 4. Sinus rhythm 5. Greater than 3 s asystole (upright or supine) during carotid sinus massage (CSM) (i.e. cardio-inhibitory carotid sinus hypersensitivity) 6. Gait, balance, and vision, as assessed by attending physician, not attributable cause of falls Initial information at time of registration: Patients with a history of unexplained falls with reproducible cardio-inhibitory or mixed carotid sinus hypersensitivity
Exclusion criteria
Exclusion criteria: Added 16/02/2009: 1. Contraindication to CSM 2. Atrial fibrillation 3. Medications which enhance vagal activity 4. Neoplasm 5. Chronic renal failure 6. Chronic liver disease 7. Heart failure (New York Heart Association [NYHA] class III/IV)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Added 16/02/2009: Number of patients who fall in the 24 months following intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Added 16/02/2009: 1. Frequency of falls 2. Dizzy symptoms and presyncope 3. Perceived health and mental status including informant?s perception and patient?s perception 4. Injury rates 5. Use of primary, secondary and tertiary care facilities 6. Length of hospital admission 7. Change in residential circumstances 8. Cognitive function | — |
Countries
United Kingdom
Outcome results
None listed