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Vitamin C and its effect on the kidneys after open heart surgery

Effect of ascorbic acid supplementation on acute kidney injury after open heart surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN98572043
Enrollment
400
Registered
2018-11-30
Start date
2018-12-01
Completion date
Unknown
Last updated
2022-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney injury Urological and Genital Diseases Acute kidney injury

Interventions

Patients will be randomized according to their day of birth - the ones on even days will be the control group (no supplement) and the ones on odd days will be the test group (supplement).

Sponsors

University Medical Center Maribor
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All adult patients requiring open heart surgical procedures, regardless of the urgency (urgent vs elective) or type of procedure (coronary revascularization, valvular surgery or aortic surgery)

Exclusion criteria

Exclusion criteria: 1. Chronic kidney failure on renal replacement therapy 2. Hyperoxalouria 3. History of kidney stones

Design outcomes

Secondary

MeasureTime frame
ROS involvement in lipid peroxidation, assessed using malondyaldehide concentration in serum measured using gas chromatography and mass spectrometry, starting intraoperatively and once a day five days postoperatively

Primary

MeasureTime frame
Kidney function assessed using creatinine and urea levels, glomerular filtration rate and diuresis, starting intraoperatively and once a day five days postoperatively

Countries

Serbia, Slovenia

Contacts

Public ContactAnze Djordjevic
anze.djordjevic@ukc-mb.si+386 (0)40 260 231

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 25, 2026