Bowel cancer Cancer
Conditions
Interventions
A randomised open controlled trial (RCT) of chromocolonoscopy (spraying blue indigo carmine dye throughout the upper large bowel during colonoscopy) vs a standard colonoscopy without dye in index bowe
Sponsors
Cardiff University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All FIT-positive people in the participating centres, eligible for index screening colonoscopy using high definition scopes
Exclusion criteria
Exclusion criteria: 1. Previous resectional colorectal surgery (as this would influence both study methods and outcomes depending on the length of residual colon in the individual) 2. Known allergy to food colouring agent (as the Indigo Carmine dye is a safe food colouring agent but extremely rarely there may be individuals with a specific allergic response to this in the past)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of any proximal advanced serrated lesions as defined by pathological assessment at index colonoscopy (colonoscopy intervention) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Pathological types and counts of all polyps detected at index procedure (colonoscopy intervention) 2. Pathological types and counts of all polyps detected at surveillance procedure (up to 1 year after repeat procedures). Types of all polyps detected at surveillance procedures will be obtained from local histopathology reports and routinely collected screening datasets 3. Cancers and deaths obtained from routinely collected health datasets (follow up for 3 years) | — |
Countries
England, Scotland, United Kingdom, Wales
Contacts
Public ContactGeorgina Gardner
Outcome results
None listed