Use of high frequency oscillatory ventilation for the prevention of chronic lung disease of prematurity: a multicentre trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN98436149

Enrollment

800

Registered

2000-10-25

Start date

1998-01-26

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic lung disease Respiratory Chronic lung disease

Interventions

1. Early intervention with high frequency oscillatory ventilation (HFOV) 2. Control

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Gestational age less than 29 weeks 2. Require endotracheal ventilation 3. It is considered appropriate that intensive care is continued 4. No identified major congenital malformation

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Composite variable: 1. Death before discharge from neonatal services 2. Chronic lung disease, defined as oxygen dependency 36 weeks post menstrual age (PMA)	—

Secondary

Measure	Time frame
1. Age at death 2. Age at final extubation 3. Failure of treatment 4. Abnormal cerebral ultrasound 5. Postnatal use of systematic steroids 6. Hearing loss greater than 60 dB 7. Pneumothorax 8. Age finally out of oxygen 9. Pulmonary haemorrhage 10. Patent ductus arteriosus 11. Retinopathy of prematurity 12. Age at discharge from hospital Long-term outcome measures: 1. Respiratory morbidity over the first two years 2. Presence of disability at two years	—

Measure

Time frame

1. Age at death 2. Age at final extubation 3. Failure of treatment 4. Abnormal cerebral ultrasound 5. Postnatal use of systematic steroids 6. Hearing loss greater than 60 dB 7. Pneumothorax 8. Age finally out of oxygen 9. Pulmonary haemorrhage 10. Patent ductus arteriosus 11. Retinopathy of prematurity 12. Age at discharge from hospital Long-term outcome measures: 1. Respiratory morbidity over the first two years 2. Presence of disability at two years

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 7, 2026