Prostate cancer Cancer Prostate
Conditions
Interventions
Standard external beam radiotherapy 55 Gy (control) versus external beam 34 Gy plus brachytherapy 17 Gy
Sponsors
NHS R&D Regional Programme Register - Department of Health (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Patients with prostatic carcinoma who after routine staging have no evidence of distant metastasis. Patients will be male and over 40 years of age. In general external beam treatment is delivered as an outpatient whilst the interstitial treatment will require two to three days inpatient care.
Exclusion criteria
Exclusion criteria: 1. Prostate specific antigen (PSA) over 50 2. Previous Transurethral Resection of the Prostate (TURP) 3. Radiological evidence of distant metastasis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. An improvement in local control for prostatic carcinoma as defined by: a. PSA response b. Changes on digital rectal examination c. Local symptom-free duration d. Quality of Life (FACT-P) 2. Prolonged disease specific survival consequent upon the improved local survival 3. Reduced bowel morbidity because of the more localised nature of the interstitial component of the radiation dose delivered | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
England, United Kingdom
Outcome results
None listed