Recurrent urethral stricture Urological and Genital Diseases Urethral stricture
Conditions
Interventions
We need to randomise at least 500 men recruited from NHS hospitals to undergo either of the two options of endoscopic urethrotomy and open urethroplasty and then follow their progress over 2 years. Du
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Adult men aged 16 years or older 2. Stricture located predominantly in bulbar urethra 3. Undergone at least one previous intervention (urethrotomy, dilatation, or urethroplasty) for bulbar stricture 4. Clinician and patient agreement that intervention is required 5. Suitable for general or regional anaesthesia of up to 3 hours duration 6. Willingness to have 2 week period of catheterisation 7. Provided written informed consent for participation in the study prior to any study specific procedures
Exclusion criteria
Exclusion criteria: 1. Age less than 16 years 2. Stricture extending into membranous urethra or predominantly sited in penile urethra 3. Presence of perineal sepsis and/or fistula 4. No previous intervention for bulbar stricture 5. High anaesthetic risk or inability to adhere to protocol due to comorbidity 6. Inability or unwillingness to provide informed consent to randomisation 7. Previous participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ICIQ-Male Short Form questionnaire repeated measurement over 24 months following intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed