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Fatigue and brain function in young people after brain injury

Characterising fatigue phenotypes and their neural underpinnings in children and young people with acquired brain injury

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN97876700
Enrollment
60
Registered
2026-04-27
Start date
2026-05-01
Completion date
Unknown
Last updated
2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive fatigue in children and young people (CYP) with acquired brain injury (ABI) Injury, Occupational Diseases, Poisoning

Interventions

Experimental design: We will recruit a convenience sample of 40 children and young people (CYP) with acquired brain injury (ABI). Prior to enrolment in the study, members of their direct care team wil

Sponsors

University of Birmingham
Lead Sponsor

Eligibility

Sex/Gender
All
Age
10 Years to 18 Years

Inclusion criteria

Inclusion criteria: Children and young people (CYP) with ABI: 1. Fatigue problems (self-reported, parent-reported or clinical findings) due to moderate to severe ABI 2. Receiving follow-up care at Birmingham Children's Hospital (BCH), with a consensus clinical diagnosis of ABI from any aetiology (i.e. traumatic or non-traumatic injury or oncology) Control participants: 1. Typical developmental history 2. No known history of neurological conditions 3. Free from any medical conditions that required medical or surgical intervention within the last 6 months Both groups: 1. Aged between 10 and 18 years 2. Ability to communicate verbally or non-verbally with their parents and researchers if they don’t feel comfortable or report any problems while undergoing MRI 3. Commitment to engage in the assessments 4. CYP with neurodiversity (e.g., autism, attention deficit hyperactive disorder) diagnosis will be considered if parents feel that they can undergo the assessments

Exclusion criteria

Exclusion criteria: Control participants: 1. History of neurological conditions 2. History of neurodevelopmental conditions Both groups: 1. Suspected or confirmed alcohol/recreational substance use 2. Suspected or confirmed pregnancy 3. Parents who lack the capacity to consent 4. MRI incompatible: metal plates incompatible with MRI scanners, pacemakers, inability to lay flat for prolonged periods, aneurysm clips, neurostimulators, brain/subdural electrodes, etc

Countries

England, United Kingdom

Contacts

Public ContactDavinia Fernández Espejo
d.fernandez-espejo@bham.ac.uk+44 (0)1214145534

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 16, 2026