Topic: Dementias and Neurodegenerative Diseases Research Network
Conditions
Interventions
1. Diffusion tensor imaging to assess white matter integrity
2. Functional imaging: functional magnetic resonance imaging (fMRI) BOLD brain scan in response to the attention network task
3. High densi
Sponsors
Northumbria Tyne and Wear NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. For dementia patients: that they meet defined clinical criteria for diagnosis of dementia (dementia with Lewy bodies, Parkinson's disease with dementia, or Alzheimer's dementia) and Mini-Mental State Examination (MMSE) test score of more than 12 2. For healthy controls: No history of psychiatric or neurological brain disease and MMSE score more than 26 and has capacity to consent to participate 3. All aged 60 years and above, either sex
Exclusion criteria
Exclusion criteria: 1. Contraindications for or unwillingness to undergo MR imaging 2. Severe dementia (MMSE score less than 12), as such subjects will have difficulty fully understanding the nature and extent of the proposed research 3. Presence of other severe or unstable medical illnesses 4. Subjects with a history of visual impairment secondary to glaucoma, cataract, or macular degeneration as this could affect the ability of subjects to perform the visual attention task with LBD 5. Medications: subjects on benzodiazepines, antipsychotics or anticonvulsants will not be included as these can effect the EEG activity patterns
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional MR BOLD activations to attentional network task, measured at end of study | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Diffusion tensor measures of white matter, measured at end of study 2. Spatio-temporal EEG activations to attentional network task, measured at end of study | — |
Countries
United Kingdom
Outcome results
None listed