Allergic diseases, e.g., atopic dermatitis, asthma and allergic rhinoconjuncitvitis Injury, Occupational Diseases, Poisoning Adverse effects, not elsewhere classified
Conditions
Interventions
After written informed consent, the medical, obstetrical and gynaecological history will be thoroughly documented, and sociodemographic data (including smoking habits of pregnant mother and her partne
Sponsors
Individual sponsor (Germany)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Pregnant women recruited at a gestational age of 8 - 12 weeks 2. Aged between 18 and 35 years old 3. Single child pregnancy 4. Full-term deliveries
Exclusion criteria
Exclusion criteria: 1. Fertility treatments and infections (human immunodeficiency virus [HIV], hepatitis B and C) 2. A history of recurrent spontaneous abortion, pre-eclampsia, or gestational diabetes in previous pregnancies 3. Sufferers of the following chronic diseases: 3.1. Inflammatory bowel diseases 3.2. Diabetes type 1 3.3. Rheumatoid and autoimmune diseases 3.4. Previous chemotherapies and radiation therapies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of environmental cues as further potential risk factors during pregnancy (e.g. living conditions, smoking habits, perceived stress, social support and nutrition) for the child's risk to develop an atopic disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigation of potential mechanism, by which environmental cues may exert a foetal programming effect towards allergic diseases during pregnancy. Here we will concentrate on endocrine, immune and neurobiological mechanisms. | — |
Countries
Canada, Germany
Outcome results
None listed