Topic: Skin
Conditions
Interventions
Participants exposing approximately 35% skin surface area will receive a single, whole body exposure to UVR of 0.8 MED. Urine collected over the following 5 days will be analysed to determine the time
Sponsors
University of Manchester (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy, ambulant human volunteers 2. Aged 18-45 years 3. Sun reactive skin types I-VI 4. Non smokers 5. Body mass index (BMI) of less than 30
Exclusion criteria
Exclusion criteria: 1. History of skin cancer or photosensitivity disorder 2. Taking photoactive medication 3. Sunbathing or sunbed use in the past 3 months 4. Taking dietary supplements containing vitamin D or antioxidants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary DNA damage; Timepoint(s): Up to 14 days post exposure | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time of maximal DNA damage product concentration in urine following acute UVR exposure 2. Minimum dose of UVR required to produce detectable levels of DNA damage in urine 3. Level of DNA damage in skin biopsy sections following acute UVR 4. Concentration of serum 25(OH)D following acute UVR exposure | — |
Countries
England, United Kingdom
Outcome results
None listed