Hepatitis C Virus in long term renal transplant recipients Infections and Infestations Hepatitis C Virus (HCV) in long term renal transplant recipients (RTR)
Conditions
Interventions
Participants will be asked to complete 2 different quality of life questionnaires (36-item Short Form Survey (SF36) and Chronic Liver Disease Questionnaire (CLDQ)) at the baseline, at the end of antiv
Sponsors
Comitato Etico "Carlo Romano", Università Federico II di Napoli
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older 2. Stable eGFR > 30 ml/min 3. Moderate liver stiffness (measured by elastography) 4. Replicating HCV infection
Exclusion criteria
Exclusion criteria: 1. Decompensated liver cirrhosis 2. Chronic hepatitis B 3. Human immunodeficiency virus infection 4. Presence of specific intercurrent clinical problems
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvements in the different domains (physical and emotional) of quality of life after viral eradication, assessed at the end of HCV antirviral therapy (12 weeks) and 1 year after its completion using the following: 1. 36-item Short Form Survey (SF36) 2. Chronic Liver Disease Questionnaire (CLDQ) | — |
Secondary
| Measure | Time frame |
|---|---|
| Kidney function, assessed by the stability of calculated glomerular filtration rate (eGFR), calculated using the CKD-EPI creatinine equation at the baseline, at the end of antiviral therapy (12 weeks) and 1 year after its completion. | — |
Countries
Italy
Contacts
Public ContactMassimo Sabbatini
Outcome results
None listed