Metastatic spinal cord compression Cancer Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
Conditions
Interventions
Radiotherapy (single or multiple fractions):
Arm 1: 20 Gy/5 fractions daily for 5 consecutive days
Arm 2: 8 Gy/1 fraction
Sponsors
University College London (UCL) (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Proven diagnosis of spinal cord compression on magnetic resonance imaging (MRI) 2. Histologically or cytologically confirmed malignant disease 3. Life expectancy greater than 1 month 4. Aged 18 years or older 5. Able to give informed consent 6. Willing and able to complete assessment forms
Exclusion criteria
Exclusion criteria: 1. Patients for whom surgery or chemotherapy treatment is more appropriate 2. Patient known to be pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient accrual per centre over a 12-month period. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ambulatory status at 1, 4, 8 and 12 weeks from day 1 of treatment compared to baseline 2. Bladder and bowel function at baseline compared to week 1, 4, 8 and 12 3. Acute side effects at week 1 and 4 assessed using Radiation Therapy Oncology Group (RTOG) scales 4. Quality of life at week 1, 4, 8 and 12, measured by the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Cancer patients (EORTC QLQ-C30) questionnaire 5. Further treatment 6. Overall survival at 3, 6 and 12 months 7. Total number of days spent in hospital 8. Preferred place of care 9. Number of patients who were eligible but not randomised and reasons for non-randomisation | — |
Countries
England, United Kingdom
Outcome results
None listed